Preparation And Invitro Evaluation of Nanocapsules by Using Tapentadol

The primary object of the current study is to form and evaluate tapentadole nano capsules. According to this study, polymers are used to prepare nano capsules by nanoprecipitation method. In this method ethyl cellulose as a key ingredient and Ethanol is used as solvent. Various formulations were produced by varying the ratios of ethyl cellulose and drug. The resulted formulations were evaluated for parameters like drug content, weight variation, invitro drug release and drug excipient compatibility, SEM, FTIR, DSC. In this method, the release profile highlydepends on concentration of polymer.

Nanotechnology is the science it means small. Nano came from the Greek word “Nano” which means small. Development of nanotechnology on the nanometer scale, usually size ranges from

to 100nm. Nano materials have established many important applications in biomedical, pharmaceutical, electronic, and molecular diagnostic fields. The polymericnanoparticle (PNPs) is prepared from biocompatible and biodegradable polymersin size between 10- 1000nm.Where the drug is dissolved, entrapped,encapsulated (or) attached to a nanoparticle’s matrix.

Method Of Preparation:

NANOPRECIPITATION METHODOR INTERFACIAL DEPOSITION OF POLYMERS.

Materials And Formulation:

Compositions of LNC-Tapentadole and LNC-blank yieldinga final volume of 10 ml nanosuspension.

• The current work is to prepare tapentadole nano capsules. From the result it is finishedthat the formulated tapentadole nano capsules are safe to use fororal route.
• In the regard we formulated nano capsules using tapentadole as an active ingredient, usingdifferent ratios of a polymer i.e. ethyl cellulose.
• The formulated nano capsule has been subjectedto entire possibleevaluation tests and the outcome obtained were within standard limits
• Further research will carryout to check scientifically for pharmacological actions of the selected formulation.