AlcrutResearch Article
Jangaon Institute of Pharmaceutical Sciences, Depot. Of Pharmaceutics, Jangaon, India.
*Corresponding Author: Stalin Reddy Challa
Citation: Stalin Reddy Challa. Formulation And Evaluation of Empagliflozin onto Zinc Oxide Nanoparticles. J. Clinical and Medical Research and Studies. 2(3) Doi: 10.59468/2836-8525/032
Copyright: © 2023 Stalin Reddy Challa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: July 02, 2023 | Accepted: July 20, 2023 | Published: July 24, 2023
Abstract
Nanospheres can be elucidated as the colloidal systems where the therapeutic agents are enclosed in a colloidal polymeric matrix.
Keywords: Nanoparticles; polymers; evaporation technique, physical mixture
Introduction
Nanospheres can be elucidated as the colloidal systems where the therapeutic agents are enclosed in a colloidal polymeric matrix [1].Usually the routes of admistration of nanospheres are oral, local and systemic and are of small particle size ,generally 10-200nm[2].nanospheres consists of drugs that are enclosed or dispersed in polymeric matrix, basically by dissolving or entrapment mechanism or encapsulation to the polymeric matrix. These nanospheres may be crystalline in nature or amorphous in nature and has the capability to save the drug from chemical and enzymatic degradation[3].Nanospheres can be produced by various types of polymers.They are included under nanotechnology and can be called as nanoparticles.
Materials And Methods
Materials: Present research work involves the usage of materials such as parecoxib, which is the Active Pharmaceutical Ingredient and Eudragit,which is polymer.Acetone is used as a solvent.The profiles of API(active pharmaceutical ingredient)/drug , polymer and solvent are discussed here.
Results And Discussion
The nanospheres that are prepared are evaluated for particle size through scanning electron microscopy and other evaluations like drug polymerinteractions through Differential scanning colorimetry and FT-IR.Entrapment Efficiency , zeta potential and invitro drug release are also evaluated for preparednanospheres.
Conclusion
From the results, It is concluded that the prepared parecoxib loaded eudragit nanospheres are of great compatibility and has a higher drug release rate and surface morphology of smooth and round surfaceswith the entrapment efficiency of 79.8±0.32. The Zeta potentialof optimized formulation F3 was found to be -19.8mV and Invitro drug releaseof 92.5±0.36%. Thus these prepared parecoxib nanospheres can be effective in treating and efficient drug delivery.
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